BRD-K62810658_PD 98059_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K62810658_PD 98059_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADGRL2 adhesion G protein-coupled receptor L2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATP11B ATPase, class VI, type 11B
AUTS2 autism susceptibility candidate 2
BSG basigin (Ok blood group)
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKB creatine kinase, brain
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DENND1B DENN/MADD domain containing 1B
EDNRA endothelin receptor type A
EGLN3 egl-9 family hypoxia-inducible factor 3
EXPH5 exophilin 5
FASN fatty acid synthase
GBP1 guanylate binding protein 1, interferon-inducible
HNMT histamine N-methyltransferase
HOPX HOP homeobox
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
LAPTM5 lysosomal protein transmembrane 5
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR6 lysophosphatidic acid receptor 6
MB myoglobin
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MTSS1 metastasis suppressor 1
NEFH neurofilament, heavy polypeptide
NID1 nidogen 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OLFML2A olfactomedin-like 2A
P3H2 prolyl 3-hydroxylase 2
PBX1 pre-B-cell leukemia homeobox 1
PCBP2 poly(rC) binding protein 2
PDLIM3 PDZ and LIM domain 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PPDPF pancreatic progenitor cell differentiation and proliferation factor
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RSAD2 radical S-adenosyl methionine domain containing 2
RTN2 reticulon 2
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPON2 spondin 2, extracellular matrix protein
STON1 stonin 1
TES testin LIM domain protein
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
XCL1 chemokine (C motif) ligand 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
ANXA5 annexin A5
CALB1 calbindin 1, 28kDa
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CIAPIN1 cytokine induced apoptosis inhibitor 1
CPVL carboxypeptidase, vitellogenic-like
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
GOLT1B golgi transport 1B
GRB14 growth factor receptor-bound protein 14
HOXC6 homeobox C6
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R2 interleukin 1 receptor, type II
IL6ST interleukin 6 signal transducer
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
MAB21L2 mab-21-like 2 (C. elegans)
MAL mal, T-cell differentiation protein
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1X metallothionein 1X
PF4 platelet factor 4
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PRR7 proline rich 7 (synaptic)
PTMA prothymosin, alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
SFRP1 secreted frizzled-related protein 1
SRSF7 serine/arginine-rich splicing factor 7
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase