BRD-K62221994_T 98475_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K62221994_T 98475_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AGTR1 angiotensin II receptor, type 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLIC4 chloride intracellular channel 4
CYBB cytochrome b-245, beta polypeptide
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELOVL5 ELOVL fatty acid elongase 5
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXO3 forkhead box O3
G6PD glucose-6-phosphate dehydrogenase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
STXBP1 syntaxin binding protein 1
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TM7SF2 transmembrane 7 superfamily member 2
TXNRD1 thioredoxin reductase 1
VCAN versican
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AEBP1 AE binding protein 1
CCNE2 cyclin E2
CDC45 cell division cycle 45
CYBA cytochrome b-245, alpha polypeptide
FANCG Fanconi anemia, complementation group G
FGFR2 fibroblast growth factor receptor 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
KRT13 keratin 13, type I
LHX2 LIM homeobox 2
MCM4 minichromosome maintenance complex component 4
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PBX3 pre-B-cell leukemia homeobox 3
PCNA proliferating cell nuclear antigen
PERP PERP, TP53 apoptosis effector
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2