BRD-K61981833_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K61981833_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CRABP1 cellular retinoic acid binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EGR1 early growth response 1
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM60A family with sequence similarity 60, member A
FGFR4 fibroblast growth factor receptor 4
FXYD3 FXYD domain containing ion transport regulator 3
GREM1 gremlin 1, DAN family BMP antagonist
IER3 immediate early response 3
KLF6 Kruppel-like factor 6
KRT15 keratin 15, type I
LIF leukemia inhibitory factor
MTSS1 metastasis suppressor 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
S100A14 S100 calcium binding protein A14
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TFF3 trefoil factor 3 (intestinal)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
VEGFA vascular endothelial growth factor A
ZNF24 zinc finger protein 24
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARG2 arginase 2
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
CD99 CD99 molecule
COL4A5 collagen, type IV, alpha 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
LAMP3 lysosomal-associated membrane protein 3
LGALS1 lectin, galactoside-binding, soluble, 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MPDZ multiple PDZ domain protein
MYH11 myosin, heavy chain 11, smooth muscle
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTK2 protein tyrosine kinase 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TBX3 T-box 3
TM4SF1 transmembrane 4 L six family member 1
TOX3 TOX high mobility group box family member 3
TSPYL5 TSPY-like 5