BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_WSUDLCL2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_WSUDLCL2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ANXA2 annexin A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
C10ORF10 chromosome 10 open reading frame 10
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRYAB crystallin, alpha B
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1 eukaryotic translation initiation factor 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GSTP1 glutathione S-transferase pi 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL1R2 interleukin 1 receptor, type II
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
MAB21L2 mab-21-like 2 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NEB nebulin
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PIR pirin (iron-binding nuclear protein)
PRAME preferentially expressed antigen in melanoma
PSAT1 phosphoserine aminotransferase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RGS1 regulator of G-protein signaling 1
RPL38 ribosomal protein L38
S100A2 S100 calcium binding protein A2
SELL selectin L
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD6 SMAD family member 6
SRGN serglycin
SYNM synemin, intermediate filament protein
TM4SF1 transmembrane 4 L six family member 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ALB albumin
ALDOA aldolase A, fructose-bisphosphate
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATF1 activating transcription factor 1
BAD BCL2-associated agonist of cell death
BBX bobby sox homolog (Drosophila)
BIK BCL2-interacting killer (apoptosis-inducing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCNE2 cyclin E2
CD200 CD200 molecule
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CLMN calmin (calponin-like, transmembrane)
COL10A1 collagen, type X, alpha 1
CPE carboxypeptidase E
CRIP1 cysteine-rich protein 1 (intestinal)
CUTA cutA divalent cation tolerance homolog (E. coli)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCLK1 doublecortin-like kinase 1
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP7 dual specificity phosphatase 7
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA3 EPH receptor A3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAP fibroblast activation protein, alpha
FST follistatin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIPK1 homeodomain interacting protein kinase 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFITM1 interferon induced transmembrane protein 1
IRS1 insulin receptor substrate 1
KLF4 Kruppel-like factor 4 (gut)
KRT23 keratin 23, type I
LMNA lamin A/C
LOC100505650 uncharacterized LOC100505650
LRRC15 leucine rich repeat containing 15
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MCF2L MCF.2 cell line derived transforming sequence-like
METRN meteorin, glial cell differentiation regulator
MTF2 metal response element binding transcription factor 2
PAX5 paired box 5
PDLIM1 PDZ and LIM domain 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PXDN peroxidasin
RBM38 RNA binding motif protein 38
RRAGD Ras-related GTP binding D
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPTSSA serine palmitoyltransferase, small subunit A
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPPP3 tubulin polymerization-promoting protein family member 3
ZBED2 zinc finger, BED-type containing 2