BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BLVRB biliverdin reductase B
C1QB complement component 1, q subcomponent, B chain
C5AR1 complement component 5a receptor 1
CBR1 carbonyl reductase 1
CD14 CD14 molecule
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP1B charged multivesicular body protein 1B
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JMJD6 jumonji domain containing 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MERTK MER proto-oncogene, tyrosine kinase
MMP3 matrix metallopeptidase 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
ODC1 ornithine decarboxylase 1
PAWR PRKC, apoptosis, WT1, regulator
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB32 RAB32, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SCRG1 stimulator of chondrogenesis 1
SEPP1 selenoprotein P, plasma, 1
SLC16A6 solute carrier family 16, member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
STC2 stanniocalcin 2
TALDO1 transaldolase 1
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ASRGL1 asparaginase like 1
C4BPA complement component 4 binding protein, alpha
CNN1 calponin 1, basic, smooth muscle
CNN3 calponin 3, acidic
CPM carboxypeptidase M
CTSH cathepsin H
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
F3 coagulation factor III (thromboplastin, tissue factor)
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
GPX1 glutathione peroxidase 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
LAMC2 laminin, gamma 2
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LITAF lipopolysaccharide-induced TNF factor
LRRC17 leucine rich repeat containing 17
MLPH melanophilin
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NCAM1 neural cell adhesion molecule 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PLAT plasminogen activator, tissue
PTCH1 patched 1
SDC1 syndecan 1
SDC2 syndecan 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SLC43A3 solute carrier family 43, member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TMC5 transmembrane channel-like 5
TMEM123 transmembrane protein 123
TMEM87A transmembrane protein 87A
TMX4 thioredoxin-related transmembrane protein 4
TPM2 tropomyosin 2 (beta)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VIM vimentin
WFDC2 WAP four-disulfide core domain 2
ZBTB18 zinc finger and BTB domain containing 18