BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_U937_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN10 claudin 10
CLDND1 claudin domain containing 1
CLIC4 chloride intracellular channel 4
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CREG1 cellular repressor of E1A-stimulated genes 1
CSRP2 cysteine and glycine-rich protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DST dystonin
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLM glutamate-cysteine ligase, modifier subunit
GHITM growth hormone inducible transmembrane protein
GJA1 gap junction protein, alpha 1, 43kDa
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
LHFPL2 lipoma HMGIC fusion partner-like 2
LPAR1 lysophosphatidic acid receptor 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MKNK1 MAP kinase interacting serine/threonine kinase 1
MTUS1 microtubule associated tumor suppressor 1
MUT methylmalonyl CoA mutase
NQO2 NAD(P)H dehydrogenase, quinone 2
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZD2 PDZ domain containing 2
PELI1 pellino E3 ubiquitin protein ligase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLIN2 perilipin 2
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
S100P S100 calcium binding protein P
SASH1 SAM and SH3 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCRG1 stimulator of chondrogenesis 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHB Src homology 2 domain containing adaptor protein B
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQSTM1 sequestosome 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDP2 tyrosyl-DNA phosphodiesterase 2
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
ZFHX4 zinc finger homeobox 4
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
C7 complement component 7
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHRDL1 chordin-like 1
CST3 cystatin C
CTPS1 CTP synthase 1
CXCR4 chemokine (C-X-C motif) receptor 4
DPH2 DPH2 homolog (S. cerevisiae)
EIF4A1 eukaryotic translation initiation factor 4A1
ENDOD1 endonuclease domain containing 1
EVL Enah/Vasp-like
EXOSC4 exosome component 4
FAM216A family with sequence similarity 216, member A
FBL fibrillarin
FEN1 flap structure-specific endonuclease 1
G0S2 G0/G1 switch 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRWD1 glutamate-rich WD repeat containing 1
GSPT1 G1 to S phase transition 1
HN1 hematological and neurological expressed 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KRT18 keratin 18, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPG lipase, endothelial
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1B microtubule-associated protein 1B
MGP matrix Gla protein
MGST2 microsomal glutathione S-transferase 2
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NUP85 nucleoporin 85kDa
PCYOX1L prenylcysteine oxidase 1 like
PDCD2 programmed cell death 2
PLAC8 placenta-specific 8
PLN phospholamban
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
PRR7 proline rich 7 (synaptic)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SCML1 sex comb on midleg-like 1 (Drosophila)
SERBP1 SERPINE1 mRNA binding protein 1
SF1 splicing factor 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC43A3 solute carrier family 43, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM43 transmembrane protein 43
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRAPPC4 trafficking protein particle complex 4
TSPAN8 tetraspanin 8
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
WDR3 WD repeat domain 3
ZPR1 ZPR1 zinc finger