BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

225 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG3 BTG family, member 3
CACYBP calcyclin binding protein
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD99 CD99 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CLIC4 chloride intracellular channel 4
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CPT1A carnitine palmitoyltransferase 1A (liver)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R1 cytochrome b5 reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DPP4 dipeptidyl-peptidase 4
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
ESRP1 epithelial splicing regulatory protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
JUN jun proto-oncogene
LGALS8 lectin, galactoside-binding, soluble, 8
LTBP2 latent transforming growth factor beta binding protein 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MOSPD1 motile sperm domain containing 1
MT1M metallothionein 1M
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK1 proprotein convertase subtilisin/kexin type 1
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
POPDC3 popeye domain containing 3
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RIOK3 RIO kinase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SQSTM1 sequestosome 1
ST18 suppression of tumorigenicity 18, zinc finger
STIP1 stress-induced phosphoprotein 1
TCP1 t-complex 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TWIST1 twist family bHLH transcription factor 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)
WBP5 WW domain binding protein 5
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
AK2 adenylate kinase 2
AKAP1 A kinase (PRKA) anchor protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
APOC2 apolipoprotein C-II
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL2 B-cell CLL/lymphoma 2
BID BH3 interacting domain death agonist
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC86 coiled-coil domain containing 86
CCND2 cyclin D2
CD37 CD37 molecule
CD53 CD53 molecule
CD93 CD93 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHD9 chromodomain helicase DNA binding protein 9
CHSY1 chondroitin sulfate synthase 1
CLEC11A C-type lectin domain family 11, member A
CSTA cystatin A (stefin A)
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCPS decapping enzyme, scavenger
DUSP6 dual specificity phosphatase 6
EVI2B ecotropic viral integration site 2B
EXOSC4 exosome component 4
EXOSC7 exosome component 7
FAM216A family with sequence similarity 216, member A
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGR FGR proto-oncogene, Src family tyrosine kinase
FLRT2 fibronectin leucine rich transmembrane protein 2
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
HCK HCK proto-oncogene, Src family tyrosine kinase
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1RN interleukin 1 receptor antagonist
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IRF8 interferon regulatory factor 8
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS1 lectin, galactoside-binding, soluble, 1
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY86 lymphocyte antigen 86
MEIS1 Meis homeobox 1
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MNDA myeloid cell nuclear differentiation antigen
MSL1 male-specific lethal 1 homolog (Drosophila)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NOP16 NOP16 nucleolar protein
NPY neuropeptide Y
NRGN neurogranin (protein kinase C substrate, RC3)
PLAC8 placenta-specific 8
PLEK pleckstrin
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PROM1 prominin 1
PTCH1 patched 1
PTDSS1 phosphatidylserine synthase 1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASE6 ribonuclease, RNase A family, k6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A8 S100 calcium binding protein A8
SAMHD1 SAM domain and HD domain 1
SDC2 syndecan 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
STARD13 StAR-related lipid transfer (START) domain containing 13
TARBP1 TAR (HIV-1) RNA binding protein 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TNC tenascin C
TRIM14 tripartite motif containing 14
TSEN2 TSEN2 tRNA splicing endonuclease subunit