BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SW948_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL15A1 collagen, type XV, alpha 1
COMP cartilage oligomeric matrix protein
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DSG3 desmoglein 3
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IL1R2 interleukin 1 receptor, type II
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MIR22HG MIR22 host gene
MMP1 matrix metallopeptidase 1
MSMB microseminoprotein, beta-
MUC4 mucin 4, cell surface associated
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PPAP2B phosphatidic acid phosphatase type 2B
RCAN1 regulator of calcineurin 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
THBS4 thrombospondin 4
TMEM47 transmembrane protein 47
TP63 tumor protein p63
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSPAN1 tetraspanin 1
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
UPK1B uroplakin 1B
VWF von Willebrand factor
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
WSB2 WD repeat and SOCS box containing 2
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C7 complement component 7
C9 complement component 9
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CUTA cutA divalent cation tolerance homolog (E. coli)
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
FABP1 fatty acid binding protein 1, liver
FGFR4 fibroblast growth factor receptor 4
GAL galanin/GMAP prepropeptide
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPM6A glycoprotein M6A
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LRRC17 leucine rich repeat containing 17
MET MET proto-oncogene, receptor tyrosine kinase
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PODXL podocalyxin-like
PROM1 prominin 1
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RET ret proto-oncogene
RUFY3 RUN and FYVE domain containing 3
SOX4 SRY (sex determining region Y)-box 4
STEAP3 STEAP family member 3, metalloreductase
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TARBP1 TAR (HIV-1) RNA binding protein 1
TFRC transferrin receptor
TSPAN12 tetraspanin 12