BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SW620_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD11 ankyrin repeat domain 11
APOE apolipoprotein E
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CD163 CD163 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
COMP cartilage oligomeric matrix protein
CTH cystathionine gamma-lyase
CTSS cathepsin S
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENAH enabled homolog (Drosophila)
EZR ezrin
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FST follistatin
FTH1 ferritin, heavy polypeptide 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI6 interferon, alpha-inducible protein 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
IL18 interleukin 18
INHBE inhibin, beta E
IPO13 importin 13
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JCHAIN joining chain of multimeric IgA and IgM
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LCN2 lipocalin 2
LHFPL2 lipoma HMGIC fusion partner-like 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MTUS1 microtubule associated tumor suppressor 1
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
OSER1 oxidative stress responsive serine-rich 1
PCDH17 protocadherin 17
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTHLH parathyroid hormone-like hormone
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RB1CC1 RB1-inducible coiled-coil 1
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBM34 RNA binding motif protein 34
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
TARS threonyl-tRNA synthetase
TBX3 T-box 3
THBS1 thrombospondin 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TP63 tumor protein p63
TRIB3 tribbles pseudokinase 3
TUFT1 tuftelin 1
TUSC3 tumor suppressor candidate 3
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANXA6 annexin A6
APMAP adipocyte plasma membrane associated protein
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
AURKA aurora kinase A
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CADPS2 Ca++-dependent secretion activator 2
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CD81 CD81 molecule
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CENPA centromere protein A
CHRDL1 chordin-like 1
CLEC11A C-type lectin domain family 11, member A
COPS7A COP9 signalosome subunit 7A
CST3 cystatin C
CTSG cathepsin G
CTSH cathepsin H
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DFNA5 deafness, autosomal dominant 5
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERLIN2 ER lipid raft associated 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FKBP10 FK506 binding protein 10, 65 kDa
FOLR1 folate receptor 1 (adult)
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GLRX5 glutaredoxin 5
GTF3A general transcription factor IIIA
H2AFX H2A histone family, member X
HMGA2 high mobility group AT-hook 2
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KAZN kazrin, periplakin interacting protein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM4B lysine (K)-specific demethylase 4B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
METRN meteorin, glial cell differentiation regulator
MLEC malectin
MRPL57 mitochondrial ribosomal protein L57
MSL1 male-specific lethal 1 homolog (Drosophila)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYCBP MYC binding protein
NAAA N-acylethanolamine acid amidase
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCGF2 polycomb group ring finger 2
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PEBP1 phosphatidylethanolamine binding protein 1
PLAC8 placenta-specific 8
PRC1 protein regulator of cytokinesis 1
PTMA prothymosin, alpha
PTTG1 pituitary tumor-transforming 1
RBP1 retinol binding protein 1, cellular
REEP5 receptor accessory protein 5
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS4 regulator of G-protein signaling 4
SACS sacsin molecular chaperone
SEPHS1 selenophosphate synthetase 1
SIDT2 SID1 transmembrane family, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPRY2 sprouty homolog 2 (Drosophila)
SRI sorcin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TGM2 transglutaminase 2
TMEM164 transmembrane protein 164
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TRAPPC3 trafficking protein particle complex 3
TRIL TLR4 interactor with leucine-rich repeats
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
UBL3 ubiquitin-like 3
WFS1 Wolfram syndrome 1 (wolframin)
ZNF185 zinc finger protein 185 (LIM domain)