BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SW480_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SW480_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
CALR calreticulin
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNA1 cyclin A1
CEP57 centrosomal protein 57kDa
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
CTH cystathionine gamma-lyase
CTSZ cathepsin Z
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK5 docking protein 5
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FN1 fibronectin 1
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IPO13 importin 13
KIF14 kinesin family member 14
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
NFIL3 nuclear factor, interleukin 3 regulated
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFD platelet derived growth factor D
PI3 peptidase inhibitor 3, skin-derived
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRKCI protein kinase C, iota
RAD51AP1 RAD51 associated protein 1
RAI14 retinoic acid induced 14
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAI2 snail family zinc finger 2
SPINK1 serine peptidase inhibitor, Kazal type 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNNT1 troponin T type 1 (skeletal, slow)
TP63 tumor protein p63
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZMYM2 zinc finger, MYM-type 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APOD apolipoprotein D
AREG amphiregulin
B3GNT1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP4 bone morphogenetic protein 4
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHI3L2 chitinase 3-like 2
CXCR4 chemokine (C-X-C motif) receptor 4
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
EPN2 epsin 2
FXYD3 FXYD domain containing ion transport regulator 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
HOPX HOP homeobox
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KLC1 kinesin light chain 1
LTBP1 latent transforming growth factor beta binding protein 1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MRPS2 mitochondrial ribosomal protein S2
NAP1L1 nucleosome assembly protein 1-like 1
NPDC1 neural proliferation, differentiation and control, 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRN1 neuritin 1
OXA1L oxidase (cytochrome c) assembly 1-like
PIP prolactin-induced protein
PODXL podocalyxin-like
RABAC1 Rab acceptor 1 (prenylated)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TRAPPC3 trafficking protein particle complex 3
TSPAN8 tetraspanin 8
ZMAT3 zinc finger, matrin-type 3