BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SKMEL1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SKMEL1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALOX15B arachidonate 15-lipoxygenase, type B
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
BAG3 BCL2-associated athanogene 3
BPIFA1 BPI fold containing family A, member 1
CEP57 centrosomal protein 57kDa
COL2A1 collagen, type II, alpha 1
COPS7A COP9 signalosome subunit 7A
CTSZ cathepsin Z
DCN decorin
DENND1B DENN/MADD domain containing 1B
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FAM129A family with sequence similarity 129, member A
FHOD3 formin homology 2 domain containing 3
FOLR1 folate receptor 1 (adult)
FYB FYN binding protein
GPRC5A G protein-coupled receptor, class C, group 5, member A
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R2 interleukin 1 receptor, type II
KIAA0355 KIAA0355
KLK11 kallikrein-related peptidase 11
LYZ lysozyme
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PENK proenkephalin
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCA protein kinase C, alpha
PRKCI protein kinase C, iota
PTPRE protein tyrosine phosphatase, receptor type, E
RAB29 RAB29, member RAS oncogene family
S100A10 S100 calcium binding protein A10
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SMCO4 single-pass membrane protein with coiled-coil domains 4
TGFBI transforming growth factor, beta-induced, 68kDa
TPD52L1 tumor protein D52-like 1
TXNRD1 thioredoxin reductase 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACTB actin, beta
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
AREG amphiregulin
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CALML5 calmodulin-like 5
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CLIC4 chloride intracellular channel 4
CP ceruloplasmin (ferroxidase)
CRIP2 cysteine-rich protein 2
CTSG cathepsin G
CXADR coxsackie virus and adenovirus receptor
DUSP10 dual specificity phosphatase 10
EDNRB endothelin receptor type B
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
F2R coagulation factor II (thrombin) receptor
GPM6A glycoprotein M6A
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GYPC glycophorin C (Gerbich blood group)
HOMER3 homer scaffolding protein 3
HOPX HOP homeobox
IDO1 indoleamine 2,3-dioxygenase 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LMO2 LIM domain only 2 (rhombotin-like 1)
MAB21L2 mab-21-like 2 (C. elegans)
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MFSD10 major facilitator superfamily domain containing 10
MMD monocyte to macrophage differentiation-associated
MSX1 msh homeobox 1
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PODXL podocalyxin-like
RCAN2 regulator of calcineurin 2
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
STOM stomatin
TNC tenascin C
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)