BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SKM1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD99 CD99 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CNTNAP2 contactin associated protein-like 2
COL18A1 collagen, type XVIII, alpha 1
COL5A2 collagen, type V, alpha 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
FAM13A family with sequence similarity 13, member A
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
LAMP3 lysosomal-associated membrane protein 3
LGALS8 lectin, galactoside-binding, soluble, 8
LOXL2 lysyl oxidase-like 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
OSER1 oxidative stress responsive serine-rich 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTPRO protein tyrosine phosphatase, receptor type, O
PXN paxillin
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIX1 SIX homeobox 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TDP2 tyrosyl-DNA phosphodiesterase 2
TESK1 testis-specific kinase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM30B transmembrane protein 30B
TNNT1 troponin T type 1 (skeletal, slow)
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AHSG alpha-2-HS-glycoprotein
APOA2 apolipoprotein A-II
APOD apolipoprotein D
CCDC85B coiled-coil domain containing 85B
CD44 CD44 molecule (Indian blood group)
CNPY2 canopy FGF signaling regulator 2
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EIF4A1 eukaryotic translation initiation factor 4A1
F12 coagulation factor XII (Hageman factor)
FAM162A family with sequence similarity 162, member A
FAM216A family with sequence similarity 216, member A
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GLS glutaminase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA8A golgin A8 family, member A
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP1 latent transforming growth factor beta binding protein 1
MGST2 microsomal glutathione S-transferase 2
MXRA7 matrix-remodelling associated 7
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPY neuropeptide Y
NREP neuronal regeneration related protein
PEG3 paternally expressed 3
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PNP purine nucleoside phosphorylase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKCD protein kinase C, delta
PRR7 proline rich 7 (synaptic)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL37A ribosomal protein L37a
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SOX11 SRY (sex determining region Y)-box 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
TFF1 trefoil factor 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TOX3 TOX high mobility group box family member 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN4 tetraspanin 4
VIM vimentin
VNN1 vanin 1
WASF3 WAS protein family, member 3
YBX1 Y box binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)