BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_RMGI_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_RMGI_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANOS1 anosmin 1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHEK2 checkpoint kinase 2
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPVL carboxypeptidase, vitellogenic-like
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGF epidermal growth factor
EGR3 early growth response 3
ELF5 E74-like factor 5 (ets domain transcription factor)
ETV1 ets variant 1
EVL Enah/Vasp-like
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GLA galactosidase, alpha
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
KCTD5 potassium channel tetramerization domain containing 5
KDM5A lysine (K)-specific demethylase 5A
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NNT nicotinamide nucleotide transhydrogenase
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PARD3 par-3 family cell polarity regulator
PITRM1 pitrilysin metallopeptidase 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBM47 RNA binding motif protein 47
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
S100A2 S100 calcium binding protein A2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRIO trio Rho guanine nucleotide exchange factor
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALB albumin
ANXA3 annexin A3
ANXA4 annexin A4
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
BLNK B-cell linker
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCR2 chemokine (C-C motif) receptor 2
CD200 CD200 molecule
CD93 CD93 molecule
CLC Charcot-Leyden crystal galectin
CPA3 carboxypeptidase A3 (mast cell)
CPOX coproporphyrinogen oxidase
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
ERBB2 erb-b2 receptor tyrosine kinase 2
EREG epiregulin
ESM1 endothelial cell-specific molecule 1
FBN2 fibrillin 2
FBXO11 F-box protein 11
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FST follistatin
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
JAG1 jagged 1
KLF6 Kruppel-like factor 6
LAMP5 lysosomal-associated membrane protein family, member 5
LIN28A lin-28 homolog A (C. elegans)
MDK midkine (neurite growth-promoting factor 2)
MMD monocyte to macrophage differentiation-associated
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCAM1 neural cell adhesion molecule 1
NLRP2 NLR family, pyrin domain containing 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NTS neurotensin
ORM1 orosomucoid 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PROCR protein C receptor, endothelial
PRTN3 proteinase 3
PYCARD PYD and CARD domain containing
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF423 zinc finger protein 423