BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_PL21_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_PL21_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BAG3 BCL2-associated athanogene 3
BPIFA1 BPI fold containing family A, member 1
CCP110 centriolar coiled coil protein 110kDa
CD163 CD163 molecule
CES1 carboxylesterase 1
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5R2 cytochrome b5 reductase 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5 eukaryotic translation initiation factor 5
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GCLM glutamate-cysteine ligase, modifier subunit
GRB10 growth factor receptor-bound protein 10
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IQGAP1 IQ motif containing GTPase activating protein 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA1598
KLHL24 kelch-like family member 24
KLK11 kallikrein-related peptidase 11
KRT19 keratin 19, type I
LAMP3 lysosomal-associated membrane protein 3
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MTUS1 microtubule associated tumor suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NQO1 NAD(P)H dehydrogenase, quinone 1
PCP4 Purkinje cell protein 4
PENK proenkephalin
PIR pirin (iron-binding nuclear protein)
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
PRUNE2 prune homolog 2 (Drosophila)
QPRT quinolinate phosphoribosyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAP2 signal transducing adaptor family member 2
TPD52 tumor protein D52
TXNRD1 thioredoxin reductase 1
UBQLN2 ubiquilin 2
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BCL2 B-cell CLL/lymphoma 2
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CLEC11A C-type lectin domain family 11, member A
DPH2 DPH2 homolog (S. cerevisiae)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENAH enabled homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM3C family with sequence similarity 3, member C
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC17 leucine rich repeat containing 17
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MEF2C myocyte enhancer factor 2C
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PEBP1 phosphatidylethanolamine binding protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PTCH1 patched 1
PTGES prostaglandin E synthase
REXO2 RNA exonuclease 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM43 transmembrane protein 43
TNS3 tensin 3
TRIB2 tribbles pseudokinase 2
WDR3 WD repeat domain 3
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF586 zinc finger protein 586