BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

287 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM17 ADAM metallopeptidase domain 17
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ANKRD12 ankyrin repeat domain 12
AQP3 aquaporin 3 (Gill blood group)
AQP8 aquaporin 8
ARMCX3 armadillo repeat containing, X-linked 3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHMP1B charged multivesicular body protein 1B
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CLC Charcot-Leyden crystal galectin
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSL cathepsin L
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
EIF1B eukaryotic translation initiation factor 1B
ELL2 elongation factor, RNA polymerase II, 2
EMC3 ER membrane protein complex subunit 3
ENAH enabled homolog (Drosophila)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR3 fibroblast growth factor receptor 3
FRS2 fibroblast growth factor receptor substrate 2
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GLA galactosidase, alpha
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA13 heat shock protein 70kDa family, member 13
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IFRD1 interferon-related developmental regulator 1
IGHMBP2 immunoglobulin mu binding protein 2
IGKC immunoglobulin kappa constant
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
IL6R interleukin 6 receptor
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIDINS220 kinase D-interacting substrate, 220kDa
KLHL21 kelch-like family member 21
KRT16 keratin 16, type I
LARP1 La ribonucleoprotein domain family, member 1
LGALS8 lectin, galactoside-binding, soluble, 8
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEU1 sialidase 1 (lysosomal sialidase)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPC1 Niemann-Pick disease, type C1
NUP98 nucleoporin 98kDa
OXSR1 oxidative stress responsive 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QKI QKI, KH domain containing, RNA binding
QPRT quinolinate phosphoribosyltransferase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RGS5 regulator of G-protein signaling 5
RHCG Rh family, C glycoprotein
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
RRAGC Ras-related GTP binding C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RYBP RING1 and YY1 binding protein
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SERINC5 serine incorporator 5
SFN stratifin
SIK3 SIK family kinase 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAP1 small ArfGAP 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPAG9 sperm associated antigen 9
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
SRGN serglycin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAC1 tachykinin, precursor 1
TALDO1 transaldolase 1
TBX2 T-box 2
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TKT transketolase
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
TXNRD1 thioredoxin reductase 1
UBE2G1 ubiquitin-conjugating enzyme E2G 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36 ZFP36 ring finger protein
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACP6 acid phosphatase 6, lysophosphatidic
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA4 annexin A4
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIK BCL2-interacting killer (apoptosis-inducing)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CD53 CD53 molecule
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CHRDL1 chordin-like 1
COG7 component of oligomeric golgi complex 7
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
CRIP2 cysteine-rich protein 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYR61 cysteine-rich, angiogenic inducer, 61
DES desmin
DPYD dihydropyrimidine dehydrogenase
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
ETV1 ets variant 1
F2R coagulation factor II (thrombin) receptor
FAM3C family with sequence similarity 3, member C
FBP1 fructose-1,6-bisphosphatase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXYD3 FXYD domain containing ion transport regulator 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GBAS glioblastoma amplified sequence
GTF3A general transcription factor IIIA
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL33 interleukin 33
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
KIAA0101 KIAA0101
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LAMA3 laminin, alpha 3
LGALS1 lectin, galactoside-binding, soluble, 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL1 lysyl oxidase-like 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
LY6E lymphocyte antigen 6 complex, locus E
LY75 lymphocyte antigen 75
LYZ lysozyme
MACF1 microtubule-actin crosslinking factor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MGP matrix Gla protein
MKL2 MKL/myocardin-like 2
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYH11 myosin, heavy chain 11, smooth muscle
MYO5C myosin VC
NFIB nuclear factor I/B
NNT nicotinamide nucleotide transhydrogenase
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PAIP1 poly(A) binding protein interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLN phospholamban
PODXL podocalyxin-like
PPARG peroxisome proliferator-activated receptor gamma
PRDX2 peroxiredoxin 2
PRSS2 protease, serine, 2 (trypsin 2)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTTG1 pituitary tumor-transforming 1
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS2 regulator of G-protein signaling 2
RNASEH2A ribonuclease H2, subunit A
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC4 syndecan 4
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SRSF7 serine/arginine-rich splicing factor 7
SULF1 sulfatase 1
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMPRSS3 transmembrane protease, serine 3
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
UBE2C ubiquitin-conjugating enzyme E2C
ZBED2 zinc finger, BED-type containing 2
ZFP36L1 ZFP36 ring finger protein-like 1