BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_NCIH508_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_NCIH508_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
BAG3 BCL2-associated athanogene 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMP cathelicidin antimicrobial peptide
CD163 CD163 molecule
CES1 carboxylesterase 1
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMP cartilage oligomeric matrix protein
CSTA cystatin A (stefin A)
CTSB cathepsin B
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DACH1 dachshund family transcription factor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSTN destrin (actin depolymerizing factor)
ELOVL6 ELOVL fatty acid elongase 6
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
EYA2 EYA transcriptional coactivator and phosphatase 2
FBLN1 fibulin 1
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
HMOX1 heme oxygenase 1
HP haptoglobin
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP7 insulin-like growth factor binding protein 7
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT6A keratin 6A, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
LOXL2 lysyl oxidase-like 2
LTBP2 latent transforming growth factor beta binding protein 2
LYPD1 LY6/PLAUR domain containing 1
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
ORM1 orosomucoid 1
PGD phosphogluconate dehydrogenase
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PXDN peroxidasin
RAB32 RAB32, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TERF2IP telomeric repeat binding factor 2, interacting protein
THBS1 thrombospondin 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
ANGPT1 angiopoietin 1
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ARHGAP6 Rho GTPase activating protein 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
CALCA calcitonin-related polypeptide alpha
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFD complement factor D (adipsin)
CHPT1 choline phosphotransferase 1
CHRDL1 chordin-like 1
CRYAB crystallin, alpha B
CXCL12 chemokine (C-X-C motif) ligand 12
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP5 dual specificity phosphatase 5
ELF5 E74-like factor 5 (ets domain transcription factor)
FABP4 fatty acid binding protein 4, adipocyte
FXYD2 FXYD domain containing ion transport regulator 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HES1 hes family bHLH transcription factor 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLK11 kallikrein-related peptidase 11
LPL lipoprotein lipase
LY75 lymphocyte antigen 75
MAGEA3 melanoma antigen family A3
MAL mal, T-cell differentiation protein
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NOV nephroblastoma overexpressed
NPY1R neuropeptide Y receptor Y1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
RBM47 RNA binding motif protein 47
SEPP1 selenoprotein P, plasma, 1
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPRY2 sprouty homolog 2 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TIMP4 TIMP metallopeptidase inhibitor 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOX3 TOX high mobility group box family member 3
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
XBP1 X-box binding protein 1
ZBTB18 zinc finger and BTB domain containing 18