BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALAS1 5'-aminolevulinate synthase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASF1A anti-silencing function 1A histone chaperone
ASPH aspartate beta-hydroxylase
BLVRB biliverdin reductase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA1 carbonic anhydrase I
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CLCA2 chloride channel accessory 2
COL4A5 collagen, type IV, alpha 5
CST7 cystatin F (leukocystatin)
CTSL cathepsin L
CXCL9 chemokine (C-X-C motif) ligand 9
CYLD cylindromatosis (turban tumor syndrome)
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DUSP1 dual specificity phosphatase 1
EGF epidermal growth factor
EGLN3 egl-9 family hypoxia-inducible factor 3
ELL2 elongation factor, RNA polymerase II, 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPC1 glypican 1
GPR87 G protein-coupled receptor 87
GPX2 glutathione peroxidase 2
GSR glutathione reductase
GULP1 GULP, engulfment adaptor PTB domain containing 1
GZMK granzyme K (granzyme 3; tryptase II)
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDS iduronate 2-sulfatase
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGB5 integrin, beta 5
JAG1 jagged 1
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LRP10 low density lipoprotein receptor-related protein 10
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
OPN3 opsin 3
OSBPL10 oxysterol binding protein-like 10
PERP PERP, TP53 apoptosis effector
PGD phosphogluconate dehydrogenase
PHKB phosphorylase kinase, beta
PIR pirin (iron-binding nuclear protein)
RAP1GAP RAP1 GTPase activating protein
REEP5 receptor accessory protein 5
RGCC regulator of cell cycle
RGS20 regulator of G-protein signaling 20
RIT1 Ras-like without CAAX 1
RNF167 ring finger protein 167
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCPEP1 serine carboxypeptidase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SPG20 spastic paraplegia 20 (Troyer syndrome)
SQSTM1 sequestosome 1
STK10 serine/threonine kinase 10
TALDO1 transaldolase 1
TDP2 tyrosyl-DNA phosphodiesterase 2
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TKT transketolase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUBA4A tubulin, alpha 4a
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UBXN4 UBX domain protein 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AOX1 aldehyde oxidase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1B anti-silencing function 1B histone chaperone
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DHFR dihydrofolate reductase
DLC1 DLC1 Rho GTPase activating protein
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FANCI Fanconi anemia, complementation group I
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREB1 growth regulation by estrogen in breast cancer 1
HEBP1 heme binding protein 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HOXC4 homeobox C4
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF1R insulin-like growth factor 1 receptor
IL17RB interleukin 17 receptor B
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KRT19 keratin 19, type I
LIG1 ligase I, DNA, ATP-dependent
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO5C myosin VC
NFIB nuclear factor I/B
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RBBP8 retinoblastoma binding protein 8
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RHOBTB3 Rho-related BTB domain containing 3
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SEPW1 selenoprotein W, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SPDEF SAM pointed domain containing ETS transcription factor
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFB3 transforming growth factor, beta 3
TMEM164 transmembrane protein 164
TMPRSS3 transmembrane protease, serine 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRPS1 trichorhinophalangeal syndrome I
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
VCAN versican
ZWINT ZW10 interacting kinetochore protein