BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_LOVO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_LOVO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARL4C ADP-ribosylation factor-like 4C
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GOLM1 golgi membrane protein 1
GSTA4 glutathione S-transferase alpha 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGHD immunoglobulin heavy constant delta
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
LYPD3 LY6/PLAUR domain containing 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NAMPT nicotinamide phosphoribosyltransferase
NET1 neuroepithelial cell transforming 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
ODC1 ornithine decarboxylase 1
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
RAD23B RAD23 homolog B (S. cerevisiae)
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
SEPT6 septin 6
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TPD52L1 tumor protein D52-like 1
TRIM16 tripartite motif containing 16
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
BEX1 brain expressed, X-linked 1
CD59 CD59 molecule, complement regulatory protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
COL13A1 collagen, type XIII, alpha 1
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
CYR61 cysteine-rich, angiogenic inducer, 61
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPYSL2 dihydropyrimidinase-like 2
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
FILIP1L filamin A interacting protein 1-like
GGT1 gamma-glutamyltransferase 1
GLIPR1 GLI pathogenesis-related 1
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD12 potassium channel tetramerization domain containing 12
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
PLN phospholamban
PLSCR4 phospholipid scramblase 4
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POSTN periostin, osteoblast specific factor
PXDN peroxidasin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
SSFA2 sperm specific antigen 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TNS3 tensin 3
VCAN versican
VNN1 vanin 1
ZNF185 zinc finger protein 185 (LIM domain)