BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAM10 ADAM metallopeptidase domain 10
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
APOC1 apolipoprotein C-I
APOD apolipoprotein D
BLVRB biliverdin reductase B
C20ORF24 chromosome 20 open reading frame 24
C3 complement component 3
CA12 carbonic anhydrase XII
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CD14 CD14 molecule
CD163 CD163 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA2 chloride channel accessory 2
CLCA4 chloride channel accessory 4
CLU clusterin
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DIO2 deiodinase, iodothyronine, type II
DST dystonin
EGFR epidermal growth factor receptor
ELOVL5 ELOVL fatty acid elongase 5
EMC3 ER membrane protein complex subunit 3
EMP1 epithelial membrane protein 1
ENDOD1 endonuclease domain containing 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP7 fatty acid binding protein 7, brain
FLG filaggrin
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GJA1 gap junction protein, alpha 1, 43kDa
GLTP glycolipid transfer protein
GLUL glutamate-ammonia ligase
GPC1 glypican 1
GPX3 glutathione peroxidase 3
GSR glutathione reductase
GSTA4 glutathione S-transferase alpha 4
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HPSE heparanase
IGFBP6 insulin-like growth factor binding protein 6
IL11 interleukin 11
IL18 interleukin 18
IL1R2 interleukin 1 receptor, type II
JAG1 jagged 1
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LOXL2 lysyl oxidase-like 2
LYPD3 LY6/PLAUR domain containing 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NOTCH3 notch 3
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
ORM1 orosomucoid 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZD2 PDZ domain containing 2
PGD phosphogluconate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PITX1 paired-like homeodomain 1
PLIN2 perilipin 2
POPDC3 popeye domain containing 3
PPAP2B phosphatidic acid phosphatase type 2B
PRDX1 peroxiredoxin 1
PTGES prostaglandin E synthase
RGCC regulator of cell cycle
RIT1 Ras-like without CAAX 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELL selectin L
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SMOX spermine oxidase
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPRR1B small proline-rich protein 1B
SQSTM1 sequestosome 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TALDO1 transaldolase 1
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIB3 tribbles pseudokinase 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VWF von Willebrand factor

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGRG6 adhesion G protein-coupled receptor G6
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
ASS1 argininosuccinate synthase 1
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CAST calpastatin
CCNE2 cyclin E2
CCNG1 cyclin G1
CCNG2 cyclin G2
CD200 CD200 molecule
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENOSF1 enolase superfamily member 1
FAM13A family with sequence similarity 13, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FILIP1L filamin A interacting protein 1-like
GATA2 GATA binding protein 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8B golgin A8 family, member B
HADH hydroxyacyl-CoA dehydrogenase
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
ICA1 islet cell autoantigen 1, 69kDa
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IL17RB interleukin 17 receptor B
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOXL1 lysyl oxidase-like 1
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LYZ lysozyme
MAN1C1 mannosidase, alpha, class 1C, member 1
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
OLFM4 olfactomedin 4
PBLD phenazine biosynthesis-like protein domain containing
PLCB4 phospholipase C, beta 4
PLCL1 phospholipase C-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLN phospholamban
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RSRP1 arginine/serine-rich protein 1
SLC38A2 solute carrier family 38, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
STMN1 stathmin 1
THBS1 thrombospondin 1
TM4SF4 transmembrane 4 L six family member 4
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TYMS thymidylate synthetase
VCAN versican
ZBTB20 zinc finger and BTB domain containing 20