BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BAG3 BCL2-associated athanogene 3
BIN1 bridging integrator 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPM carboxypeptidase M
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT4 DNA-damage-inducible transcript 4
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GIMAP4 GTPase, IMAP family member 4
GMPR guanosine monophosphate reductase
GOLM1 golgi membrane protein 1
GPX2 glutathione peroxidase 2
GSTP1 glutathione S-transferase pi 1
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
LMO4 LIM domain only 4
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PIR pirin (iron-binding nuclear protein)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCPEP1 serine carboxypeptidase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TALDO1 transaldolase 1
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AREG amphiregulin
BEX1 brain expressed, X-linked 1
C7 complement component 7
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CHN2 chimerin 2
CPA3 carboxypeptidase A3 (mast cell)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EREG epiregulin
FBXO11 F-box protein 11
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRB14 growth factor receptor-bound protein 14
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KANK2 KN motif and ankyrin repeat domains 2
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1C1 mannosidase, alpha, class 1C, member 1
MT2A metallothionein 2A
OLFM4 olfactomedin 4
PLAT plasminogen activator, tissue
PNMAL1 paraneoplastic Ma antigen family-like 1
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RGS13 regulator of G-protein signaling 13
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRED2 sprouty-related, EVH1 domain containing 2
TF transferrin
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNS3 tensin 3
TUBB tubulin, beta class I
VCAN versican