BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HCT116_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABHD4 abhydrolase domain containing 4
ADA adenosine deaminase
ADM adrenomedullin
AEBP1 AE binding protein 1
AHNAK2 AHNAK nucleoprotein 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CD52 CD52 molecule
CD9 CD9 molecule
CES1 carboxylesterase 1
CLCA2 chloride channel accessory 2
CLGN calmegin
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
CTSB cathepsin B
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTT DNA nucleotidylexotransferase
DSG3 desmoglein 3
EGR2 early growth response 2
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGLL1 immunoglobulin lambda-like polypeptide 1
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LRMP lymphoid-restricted membrane protein
LYPD3 LY6/PLAUR domain containing 3
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MICALL1 MICAL-like 1
MMP19 matrix metallopeptidase 19
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
PDZK1IP1 PDZK1 interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PLXNB2 plexin B2
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRKCI protein kinase C, iota
RGCC regulator of cell cycle
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SBF1 SET binding factor 1
SC5D sterol-C5-desaturase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SFTPD surfactant protein D
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS2 suppressor of cytokine signaling 2
SPARCL1 SPARC-like 1 (hevin)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
TCF4 transcription factor 4
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM29 tripartite motif containing 29
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRE5 adhesion G protein-coupled receptor E5
ASCL1 achaete-scute family bHLH transcription factor 1
ATPIF1 ATPase inhibitory factor 1
AXL AXL receptor tyrosine kinase
CCND1 cyclin D1
CDC25B cell division cycle 25B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CRABP1 cellular retinoic acid binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEPTOR DEP domain containing MTOR-interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM105A family with sequence similarity 105, member A
FAM171A1 family with sequence similarity 171, member A1
FCGBP Fc fragment of IgG binding protein
GOLM1 golgi membrane protein 1
HOXA10 homeobox A10
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITGA6 integrin, alpha 6
KLF2 Kruppel-like factor 2
KLHL21 kelch-like family member 21
KLHL41 kelch-like family member 41
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MGLL monoglyceride lipase
MNDA myeloid cell nuclear differentiation antigen
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDE4B phosphodiesterase 4B, cAMP-specific
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PSPH phosphoserine phosphatase
PTCH1 patched 1
RBP1 retinol binding protein 1, cellular
RPL36 ribosomal protein L36
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPHS1 selenophosphate synthetase 1
SEPW1 selenoprotein W, 1
SFRP1 secreted frizzled-related protein 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SRGN serglycin
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WFDC2 WAP four-disulfide core domain 2