BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AHCYL2 adenosylhomocysteinase-like 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
BAG3 BCL2-associated athanogene 3
C6ORF62 chromosome 6 open reading frame 62
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COCH cochlin
CTSL cathepsin L
CYTL1 cytokine-like 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLA galactosidase, alpha
GPC1 glypican 1
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IER5 immediate early response 5
ITGA6 integrin, alpha 6
LIMCH1 LIM and calponin homology domains 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSRB1 methionine sulfoxide reductase B1
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PLEC plectin
PLIN2 perilipin 2
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RIT1 Ras-like without CAAX 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPP1 secreted phosphoprotein 1
TALDO1 transaldolase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TRIM16 tripartite motif containing 16
TSPAN7 tetraspanin 7
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
C10ORF10 chromosome 10 open reading frame 10
COL4A1 collagen, type IV, alpha 1
ESR1 estrogen receptor 1
GTPBP8 GTP-binding protein 8 (putative)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LUM lumican
MTA1 metastasis associated 1
MUC16 mucin 16, cell surface associated
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBBP4 retinoblastoma binding protein 4
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TM4SF4 transmembrane 4 L six family member 4
TPM1 tropomyosin 1 (alpha)