BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

409 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACBD3 acyl-CoA binding domain containing 3
ADAT1 adenosine deaminase, tRNA-specific 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIM2 absent in melanoma 2
AKAP13 A kinase (PRKA) anchor protein 13
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALAS1 5'-aminolevulinate synthase 1
ANKRD11 ankyrin repeat domain 11
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BRAP BRCA1 associated protein
BRD4 bromodomain containing 4
C18ORF8 chromosome 18 open reading frame 8
CA2 carbonic anhydrase II
CAMP cathelicidin antimicrobial peptide
CAPN6 calpain 6
CARS cysteinyl-tRNA synthetase
CD14 CD14 molecule
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC34 cell division cycle 34
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
CYB5R2 cytochrome b5 reductase 2
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFA4 defensin, alpha 4, corticostatin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DTNA dystrobrevin, alpha
DUSP6 dual specificity phosphatase 6
EGFL6 EGF-like-domain, multiple 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF13 fibroblast growth factor 13
FGG fibrinogen gamma chain
FOXO1 forkhead box O1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GNLY granulysin
GTPBP2 GTP binding protein 2
HBB hemoglobin, beta
HECA headcase homolog (Drosophila)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IL13RA2 interleukin 13 receptor, alpha 2
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL24 kelch-like family member 24
KYNU kynureninase
LHFPL2 lipoma HMGIC fusion partner-like 2
LIMS1 LIM and senescent cell antigen-like domains 1
LITAF lipopolysaccharide-induced TNF factor
LPAR1 lysophosphatidic acid receptor 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MNDA myeloid cell nuclear differentiation antigen
NAMPT nicotinamide phosphoribosyltransferase
NCAM1 neural cell adhesion molecule 1
NPC1 Niemann-Pick disease, type C1
OSBPL1A oxysterol binding protein-like 1A
PELI1 pellino E3 ubiquitin protein ligase 1
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCD protein kinase C, delta
PRRC2C proline-rich coiled-coil 2C
PSAP prosaposin
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RNF24 ring finger protein 24
RRAGD Ras-related GTP binding D
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEC63 SEC63 homolog (S. cerevisiae)
SLC38A1 solute carrier family 38, member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STX3 syntaxin 3
TACC2 transforming, acidic coiled-coil containing protein 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TM6SF1 transmembrane 6 superfamily member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TRIM36 tripartite motif containing 36
UBXN7 UBX domain protein 7
UPP1 uridine phosphorylase 1
USP47 ubiquitin specific peptidase 47
WARS tryptophanyl-tRNA synthetase
ZC3H15 zinc finger CCCH-type containing 15
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF271P zinc finger protein 271, pseudogene
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD14A abhydrolase domain containing 14A
ACAT2 acetyl-CoA acetyltransferase 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
AGA aspartylglucosaminidase
AK4 adenylate kinase 4
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALG6 ALG6, alpha-1,3-glucosyltransferase
ANXA4 annexin A4
ANXA6 annexin A6
ARL3 ADP-ribosylation factor-like 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
AURKA aurora kinase A
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C5ORF15 chromosome 5 open reading frame 15
C6ORF62 chromosome 6 open reading frame 62
CALD1 caldesmon 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CBX3 chromobox homolog 3
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNG1 cyclin G1
CD320 CD320 molecule
CDCA3 cell division cycle associated 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CFI complement factor I
CLIC3 chloride intracellular channel 3
COA3 cytochrome c oxidase assembly factor 3
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COL8A1 collagen, type VIII, alpha 1
COMP cartilage oligomeric matrix protein
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CRELD2 cysteine-rich with EGF-like domains 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
CYCS cytochrome c, somatic
CYTH1 cytohesin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DCN decorin
DCPS decapping enzyme, scavenger
DCXR dicarbonyl/L-xylulose reductase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDHD2 DDHD domain containing 2
DEPTOR DEP domain containing MTOR-interacting protein
DERA deoxyribose-phosphate aldolase (putative)
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPEP1 dipeptidase 1 (renal)
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
EBP emopamil binding protein (sterol isomerase)
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
ERAP2 endoplasmic reticulum aminopeptidase 2
ERLIN1 ER lipid raft associated 1
ESD esterase D
FAM162A family with sequence similarity 162, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FKBP10 FK506 binding protein 10, 65 kDa
FKBP11 FK506 binding protein 11, 19 kDa
FKBP3 FK506 binding protein 3, 25kDa
FLG filaggrin
FLRT2 fibronectin leucine rich transmembrane protein 2
FOCAD focadhesin
FST follistatin
FSTL1 follistatin-like 1
FUCA1 fucosidase, alpha-L- 1, tissue
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GMDS GDP-mannose 4,6-dehydratase
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
HADH hydroxyacyl-CoA dehydrogenase
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HMGB2 high mobility group box 2
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IL1RAP interleukin 1 receptor accessory protein
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JCHAIN joining chain of multimeric IgA and IgM
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
LAGE3 L antigen family, member 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LIPA lipase A, lysosomal acid, cholesterol esterase
LMCD1 LIM and cysteine-rich domains 1
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LTBP2 latent transforming growth factor beta binding protein 2
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MAT2B methionine adenosyltransferase II, beta
MBNL1 muscleblind-like splicing regulator 1
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEIS1 Meis homeobox 1
MLANA melan-A
MOK MOK protein kinase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MVP major vault protein
MYLK myosin light chain kinase
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX8 paired box 8
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZK1IP1 PDZK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PFKL phosphofructokinase, liver
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PGRMC2 progesterone receptor membrane component 2
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX4 peroxiredoxin 4
PRKCZ protein kinase C, zeta
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
PYGL phosphorylase, glycogen, liver
RACGAP1 Rac GTPase activating protein 1
RGS1 regulator of G-protein signaling 1
RPL36AL ribosomal protein L36a-like
RPS27L ribosomal protein S27-like
RRAGA Ras-related GTP binding A
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SEPT11 septin 11
SEPT8 septin 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35E2B solute carrier family 35, member E2B
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TCTN3 tectonic family member 3
THY1 Thy-1 cell surface antigen
TMEM106B transmembrane protein 106B
TMEM106C transmembrane protein 106C
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
TSPO translocator protein (18kDa)
TUBB tubulin, beta class I
TXNDC15 thioredoxin domain containing 15
TYMS thymidylate synthetase
VCAN versican
VKORC1 vitamin K epoxide reductase complex, subunit 1
ZCCHC24 zinc finger, CCHC domain containing 24