BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_H1299_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADGRL2 adhesion G protein-coupled receptor L2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
DHDDS dehydrodolichyl diphosphate synthase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFHD1 EF-hand domain family, member D1
EGF epidermal growth factor
EIF5 eukaryotic translation initiation factor 5
EMX2 empty spiracles homeobox 2
GCLM glutamate-cysteine ligase, modifier subunit
GJA1 gap junction protein, alpha 1, 43kDa
GLA galactosidase, alpha
GSR glutathione reductase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IPO13 importin 13
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NDNF neuron-derived neurotrophic factor
NEFL neurofilament, light polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
P3H2 prolyl 3-hydroxylase 2
PIR pirin (iron-binding nuclear protein)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGIS prostaglandin I2 (prostacyclin) synthase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX7 sorting nexin 7
TCF4 transcription factor 4
TCP1 t-complex 1
TGFBI transforming growth factor, beta-induced, 68kDa
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
ANXA6 annexin A6
AREG amphiregulin
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BASP1 brain abundant, membrane attached signal protein 1
BIRC3 baculoviral IAP repeat containing 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CCNF cyclin F
CD81 CD81 molecule
CLIC3 chloride intracellular channel 3
CRELD2 cysteine-rich with EGF-like domains 2
CST3 cystatin C
CXCL13 chemokine (C-X-C motif) ligand 13
CYBA cytochrome b-245, alpha polypeptide
DCXR dicarbonyl/L-xylulose reductase
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EXOSC4 exosome component 4
FAM46C family with sequence similarity 46, member C
FHL1 four and a half LIM domains 1
GLDC glycine dehydrogenase (decarboxylating)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LY6E lymphocyte antigen 6 complex, locus E
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSH6 mutS homolog 6
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PENK proenkephalin
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKCZ protein kinase C, zeta
PRR7 proline rich 7 (synaptic)
PRSS21 protease, serine, 21 (testisin)
RBM34 RNA binding motif protein 34
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TNFAIP6 tumor necrosis factor, alpha-induced protein 6