BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_DV90_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_DV90_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD3 abhydrolase domain containing 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARG2 arginase 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CACYBP calcyclin binding protein
CBR3 carbonyl reductase 3
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL2A1 collagen, type II, alpha 1
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBP1 fructose-1,6-bisphosphatase 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GREB1 growth regulation by estrogen in breast cancer 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFNGR1 interferon gamma receptor 1
IRF6 interferon regulatory factor 6
JUN jun proto-oncogene
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MIR22HG MIR22 host gene
MNDA myeloid cell nuclear differentiation antigen
MUC4 mucin 4, cell surface associated
NFIL3 nuclear factor, interleukin 3 regulated
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PBX3 pre-B-cell leukemia homeobox 3
PEG3 paternally expressed 3
PGD phosphogluconate dehydrogenase
PHACTR2 phosphatase and actin regulator 2
PIR pirin (iron-binding nuclear protein)
PRKCD protein kinase C, delta
PSAP prosaposin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PXDN peroxidasin
RBMS1 RNA binding motif, single stranded interacting protein 1
S100A9 S100 calcium binding protein A9
SCPEP1 serine carboxypeptidase 1
SEC63 SEC63 homolog (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TACC2 transforming, acidic coiled-coil containing protein 2
TBX3 T-box 3
TM4SF1 transmembrane 4 L six family member 1
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
APOLD1 apolipoprotein L domain containing 1
B3GNT1
BCL2L1 BCL2-like 1
BTN3A2 butyrophilin, subfamily 3, member A2
CA12 carbonic anhydrase XII
CALB1 calbindin 1, 28kDa
CCND1 cyclin D1
CCND2 cyclin D2
CDC25B cell division cycle 25B
CELF2 CUGBP, Elav-like family member 2
CFI complement factor I
ERBB2 erb-b2 receptor tyrosine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FOXG1 forkhead box G1
FSTL1 follistatin-like 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GREM1 gremlin 1, DAN family BMP antagonist
HCP5 HLA complex P5 (non-protein coding)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HOXA10 homeobox A10
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LY75 lymphocyte antigen 75
MARCKS myristoylated alanine-rich protein kinase C substrate
MCUR1 mitochondrial calcium uniporter regulator 1
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
OXTR oxytocin receptor
PDGFC platelet derived growth factor C
PIP prolactin-induced protein
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLK1 polo-like kinase 1
PRDX2 peroxiredoxin 2
PSIP1 PC4 and SFRS1 interacting protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RNF167 ring finger protein 167
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TKTL1 transketolase-like 1
TSPAN12 tetraspanin 12
TSTA3 tissue specific transplantation antigen P35B
WDTC1 WD and tetratricopeptide repeats 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1