BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_A673_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
C20ORF24 chromosome 20 open reading frame 24
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN10 claudin 10
CLGN calmegin
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IQCG IQ motif containing G
KLF4 Kruppel-like factor 4 (gut)
LAPTM4B lysosomal protein transmembrane 4 beta
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
NBPF10 neuroblastoma breakpoint family, member 10
NQO1 NAD(P)H dehydrogenase, quinone 1
PAPOLA poly(A) polymerase alpha
PIGG phosphatidylinositol glycan anchor biosynthesis, class G
PIR pirin (iron-binding nuclear protein)
PLAU plasminogen activator, urokinase
POPDC3 popeye domain containing 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TRIM16 tripartite motif containing 16
TSPAN7 tetraspanin 7
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VLDLR very low density lipoprotein receptor
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XAF1 XIAP associated factor 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADA adenosine deaminase
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC109B coiled-coil domain containing 109B
CCL19 chemokine (C-C motif) ligand 19
CCNE2 cyclin E2
CHGB chromogranin B
CXCL9 chemokine (C-X-C motif) ligand 9
FAM198B family with sequence similarity 198, member B
FAM49A family with sequence similarity 49, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
HES1 hes family bHLH transcription factor 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN1C1 mannosidase, alpha, class 1C, member 1
MMP9 matrix metallopeptidase 9
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDLIM3 PDZ and LIM domain 3
PLK1 polo-like kinase 1
PLN phospholamban
PPA1 pyrophosphatase (inorganic) 1
PXDC1 PX domain containing 1
REEP1 receptor accessory protein 1
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A1 S100 calcium binding protein A1
SCGB2A2 secretoglobin, family 2A, member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SOX11 SRY (sex determining region Y)-box 11
TCF4 transcription factor 4
TLR4 toll-like receptor 4
TNS3 tensin 3
WFDC1 WAP four-disulfide core domain 1