BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K61033289_15-Deoxy-?12,14-prostaglandin J2_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACOT7 acyl-CoA thioesterase 7
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARG2 arginase 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
COL3A1 collagen, type III, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGF2R insulin-like growth factor 2 receptor
IGL immunoglobulin lambda locus
INHBE inhibin, beta E
ISLR immunoglobulin superfamily containing leucine-rich repeat
JMJD6 jumonji domain containing 6
LY96 lymphocyte antigen 96
MAPT microtubule-associated protein tau
MARS methionyl-tRNA synthetase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
NFE2L1 nuclear factor, erythroid 2-like 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SESN1 sestrin 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACD adrenocortical dysplasia homolog (mouse)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCNF cyclin F
CP ceruloplasmin (ferroxidase)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FHL1 four and a half LIM domains 1
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IRS2 insulin receptor substrate 2
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MEIS1 Meis homeobox 1
MSLN mesothelin
NFIB nuclear factor I/B
NR2F6 nuclear receptor subfamily 2, group F, member 6
PNMA2 paraneoplastic Ma antigen 2
PPARG peroxisome proliferator-activated receptor gamma
RFC5 replication factor C (activator 1) 5, 36.5kDa
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM2D3 TM2 domain containing 3
TM4SF1 transmembrane 4 L six family member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
UPK1B uroplakin 1B
VCAN versican
WEE1 WEE1 G2 checkpoint kinase