BRD-K60866521_idelalisib_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K60866521_idelalisib_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNM1 dynamin 1
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EML3 echinoderm microtubule associated protein like 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM63A family with sequence similarity 63, member A
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
HSPB8 heat shock 22kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KAZN kazrin, periplakin interacting protein
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LGALS8 lectin, galactoside-binding, soluble, 8
MCOLN1 mucolipin 1
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
OPN3 opsin 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAX8 paired box 8
PCP4 Purkinje cell protein 4
PRUNE prune exopolyphosphatase
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS2 regulator of G-protein signaling 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOX9 SRY (sex determining region Y)-box 9
TPD52L1 tumor protein D52-like 1

decreased expression

Symbol Name
BTG3 BTG family, member 3
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
COL4A6 collagen, type IV, alpha 6
CX3CR1 chemokine (C-X3-C motif) receptor 1
DUSP6 dual specificity phosphatase 6
EPCAM epithelial cell adhesion molecule
H2AFV H2A histone family, member V
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
KRT19 keratin 19, type I
KRT20 keratin 20, type I
MPO myeloperoxidase
MXRA7 matrix-remodelling associated 7
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCG5 secretogranin V
SH3GLB1 SH3-domain GRB2-like endophilin B1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SST somatostatin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TSPAN12 tetraspanin 12
ZIC1 Zic family member 1