BRD-K60070073_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K60070073_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BLVRB biliverdin reductase B
BTG1 B-cell translocation gene 1, anti-proliferative
CA1 carbonic anhydrase I
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CD2 CD2 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CECR1 cat eye syndrome chromosome region, candidate 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSTA cystatin A (stefin A)
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ELANE elastase, neutrophil expressed
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGF13 fibroblast growth factor 13
FTH1 ferritin, heavy polypeptide 1
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL15 interleukin 15
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KYNU kynureninase
LTF lactotransferrin
MARS methionyl-tRNA synthetase
MNDA myeloid cell nuclear differentiation antigen
NCK1 NCK adaptor protein 1
NGRN neugrin, neurite outgrowth associated
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLAMF7 SLAM family member 7
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
STAR steroidogenic acute regulatory protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
VLDLR very low density lipoprotein receptor
WARS tryptophanyl-tRNA synthetase
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALCAM activated leukocyte cell adhesion molecule
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
CD24 CD24 molecule
F2R coagulation factor II (thrombin) receptor
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
GPSM2 G-protein signaling modulator 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IL1RAP interleukin 1 receptor accessory protein
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MT1E metallothionein 1E
MYCBP MYC binding protein
NFIB nuclear factor I/B
NSG1 neuron specific gene family member 1
PNMA2 paraneoplastic Ma antigen 2
PRR7 proline rich 7 (synaptic)
RBP4 retinol binding protein 4, plasma
TYRP1 tyrosinase-related protein 1
VDAC1 voltage-dependent anion channel 1