BRD-K59962020_1-(3, 5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone SP-5-111_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K59962020_1-(3, 5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone SP-5-111_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C1R complement component 1, r subcomponent
CD99 CD99 molecule
CFB complement factor B
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
CPD carboxypeptidase D
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
FAM129A family with sequence similarity 129, member A
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP2 guanylate binding protein 2, interferon-inducible
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
MDK midkine (neurite growth-promoting factor 2)
MXRA5 matrix-remodelling associated 5
NRCAM neuronal cell adhesion molecule
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
RAP1GAP RAP1 GTPase activating protein
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VAT1 vesicle amine transport 1
VGLL4 vestigial-like family member 4
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CKS2 CDC28 protein kinase regulatory subunit 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
HSPH1 heat shock 105kDa/110kDa protein 1
IGL immunoglobulin lambda locus
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PRC1 protein regulator of cytokinesis 1
RACGAP1 Rac GTPase activating protein 1
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SDC2 syndecan 2
SGK1 serum/glucocorticoid regulated kinase 1
SHCBP1 SHC SH2-domain binding protein 1
SMC1A structural maintenance of chromosomes 1A
TSPYL5 TSPY-like 5
ZWINT ZW10 interacting kinetochore protein