BRD-K59962020_1-(3, 5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone SP-5-111_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K59962020_1-(3, 5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone SP-5-111_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CORO1A coronin, actin binding protein, 1A
CPB1 carboxypeptidase B1 (tissue)
CRABP1 cellular retinoic acid binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGHM immunoglobulin heavy constant mu
IGLL1 immunoglobulin lambda-like polypeptide 1
INHBB inhibin, beta B
INSM1 insulinoma-associated 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIAA0196 KIAA0196
KRT14 keratin 14, type I
MAP1B microtubule-associated protein 1B
MME membrane metallo-endopeptidase
MMP2 matrix metallopeptidase 2
MSN moesin
NES nestin
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKX protein kinase, X-linked
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
TNS1 tensin 1
TRIB3 tribbles pseudokinase 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AMD1 adenosylmethionine decarboxylase 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BRD2 bromodomain containing 2
CDC14B cell division cycle 14B
CDKN3 cyclin-dependent kinase inhibitor 3
CHPT1 choline phosphotransferase 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
FGF13 fibroblast growth factor 13
FUCA1 fucosidase, alpha-L- 1, tissue
GLUL glutamate-ammonia ligase
HEXIM1 hexamethylene bis-acetamide inducible 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF20A kinesin family member 20A
MAGEA3 melanoma antigen family A3
MAMLD1 mastermind-like domain containing 1
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MYBPC1 myosin binding protein C, slow type
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
NR2F2 nuclear receptor subfamily 2, group F, member 2
PKN2 protein kinase N2
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RAD51C RAD51 paralog C
SET SET nuclear proto-oncogene
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SON SON DNA binding protein
SORD sorbitol dehydrogenase
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TXNIP thioredoxin interacting protein