BRD-K59761766_6,6-dimethyl-3-(methylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid MAY_6_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-K59761766_6,6-dimethyl-3-(methylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid MAY_6_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOA1 apolipoprotein A-I
C10ORF10 chromosome 10 open reading frame 10
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
FN1 fibronectin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGLL1 immunoglobulin lambda-like polypeptide 1
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4DIP phosphodiesterase 4D interacting protein
PTPRO protein tyrosine phosphatase, receptor type, O
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF4 transmembrane 4 L six family member 4
TYMS thymidylate synthetase
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CCNE2 cyclin E2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHMP4A charged multivesicular body protein 4A
COTL1 coactosin-like F-actin binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
EMP3 epithelial membrane protein 3
FHL1 four and a half LIM domains 1
GOLM1 golgi membrane protein 1
HAT1 histone acetyltransferase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
JUNB jun B proto-oncogene
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NANS N-acetylneuraminic acid synthase
NEFH neurofilament, heavy polypeptide
NGRN neugrin, neurite outgrowth associated
PPIG peptidylprolyl isomerase G (cyclophilin G)
R3HDM4 R3H domain containing 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TLE2 transducin-like enhancer of split 2