BRD-K59469039_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K59469039_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BRD4 bromodomain containing 4
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CLDN4 claudin 4
CORO1C coronin, actin binding protein, 1C
CPM carboxypeptidase M
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNMBP dynamin binding protein
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
FAM60A family with sequence similarity 60, member A
FBP1 fructose-1,6-bisphosphatase 1
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HAPLN1 hyaluronan and proteoglycan link protein 1
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2BC histone cluster 1, H2bc
IER2 immediate early response 2
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP1 insulin-like growth factor binding protein 1
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP2K3 mitogen-activated protein kinase kinase 3
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MGLL monoglyceride lipase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PTX3 pentraxin 3, long
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RIPK2 receptor-interacting serine-threonine kinase 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
STK17A serine/threonine kinase 17a
TGFA transforming growth factor, alpha
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBXN7 UBX domain protein 7
VWF von Willebrand factor
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ANOS1 anosmin 1
C6ORF62 chromosome 6 open reading frame 62
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD99 CD99 molecule
CDC25A cell division cycle 25A
CETN2 centrin, EF-hand protein, 2
CKB creatine kinase, brain
CLU clusterin
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
DCN decorin
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
FASTKD5 FAST kinase domains 5
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
FUBP1 far upstream element (FUSE) binding protein 1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
IQGAP1 IQ motif containing GTPase activating protein 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMO3 LIM domain only 3 (rhombotin-like 2)
LTF lactotransferrin
LUM lumican
MAT2A methionine adenosyltransferase II, alpha
MCM10 minichromosome maintenance complex component 10
MEIS1 Meis homeobox 1
METTL3 methyltransferase like 3
MMP9 matrix metallopeptidase 9
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PDZD2 PDZ domain containing 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNISR PNN-interacting serine/arginine-rich protein
REEP1 receptor accessory protein 1
RRM2 ribonucleotide reductase M2
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNN stannin
SPARCL1 SPARC-like 1 (hevin)
TAGLN transgelin
TARDBP TAR DNA binding protein