BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BRCA1 breast cancer 1, early onset
C6ORF48 chromosome 6 open reading frame 48
CAPN1 calpain 1, (mu/I) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CCNG1 cyclin G1
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPU centromere protein U
COL11A1 collagen, type XI, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DGKA diacylglycerol kinase, alpha 80kDa
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP1 epithelial membrane protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM111A family with sequence similarity 111, member A
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS7 growth arrest-specific 7
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HEBP1 heme binding protein 1
HLA-B major histocompatibility complex, class I, B
IL6ST interleukin 6 signal transducer
KIAA0101 KIAA0101
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LIG1 ligase I, DNA, ATP-dependent
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MX2 MX dynamin-like GTPase 2
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRL platelet-derived growth factor receptor-like
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCARD PYD and CARD domain containing
RAB29 RAB29, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RCAN1 regulator of calcineurin 1
RHOC ras homolog family member C
SDC2 syndecan 2
SEPW1 selenoprotein W, 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNN stannin
SORBS3 sorbin and SH3 domain containing 3
STMN1 stathmin 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM106C transmembrane protein 106C
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TYMS thymidylate synthetase
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOC1 apolipoprotein C-I
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BOP1 block of proliferation 1
C1QB complement component 1, q subcomponent, B chain
C7 complement component 7
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCND2 cyclin D2
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
DACH1 dachshund family transcription factor 1
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBNA1BP2 EBNA1 binding protein 2
EIF3B eukaryotic translation initiation factor 3, subunit B
FLRT3 fibronectin leucine rich transmembrane protein 3
G0S2 G0/G1 switch 2
GATA6 GATA binding protein 6
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2BD histone cluster 1, H2bd
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
INSIG1 insulin induced gene 1
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LEFTY1 left-right determination factor 1
LMNB2 lamin B2
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUM lumican
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDNF neuron-derived neurotrophic factor
NEBL nebulette
NEFH neurofilament, heavy polypeptide
ODC1 ornithine decarboxylase 1
PAK1IP1 PAK1 interacting protein 1
PUS7 pseudouridylate synthase 7 (putative)
S100P S100 calcium binding protein P
SCARB1 scavenger receptor class B, member 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPC surfactant protein C
SQLE squalene epoxidase
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
THSD7A thrombospondin, type I, domain containing 7A
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
UBE2S ubiquitin-conjugating enzyme E2S
WT1 Wilms tumor 1