BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AIM2 absent in melanoma 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAX BCL2-associated X protein
BCL2L1 BCL2-like 1
BCL6 B-cell CLL/lymphoma 6
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C9ORF16 chromosome 9 open reading frame 16
CCDC85B coiled-coil domain containing 85B
CCNE2 cyclin E2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CMC4 C-x(9)-C motif containing 4
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DDT D-dopachrome tautomerase
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
GAA glucosidase, alpha; acid
GRAMD3 GRAM domain containing 3
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
H1F0 H1 histone family, member 0
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
IL6 interleukin 6
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
ITGB4 integrin, beta 4
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
MACROD1 MACRO domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MOK MOK protein kinase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM1 PDZ and LIM domain 1
PDLIM4 PDZ and LIM domain 4
PGLS 6-phosphogluconolactonase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RABAC1 Rab acceptor 1 (prenylated)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SCGB1D2 secretoglobin, family 1D, member 2
SDC4 syndecan 4
SERINC3 serine incorporator 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SPAG7 sperm associated antigen 7
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF1 trefoil factor 1
THBS2 thrombospondin 2
TP53TG1 TP53 target 1 (non-protein coding)
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
WDR13 WD repeat domain 13
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ANKRD10 ankyrin repeat domain 10
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
CST1 cystatin SN
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
EIF5 eukaryotic translation initiation factor 5
ELAVL1 ELAV like RNA binding protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FOXM1 forkhead box M1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GTF2A2 general transcription factor IIA, 2, 12kDa
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
KAZN kazrin, periplakin interacting protein
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIF5B kinesin family member 5B
KLHDC10 kelch domain containing 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB2 lamin B2
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MKI67 marker of proliferation Ki-67
MMP7 matrix metallopeptidase 7
MTDH metadherin
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NEK2 NIMA-related kinase 2
NOP56 NOP56 ribonucleoprotein
PBK PDZ binding kinase
PDZK1IP1 PDZK1 interacting protein 1
PLK1 polo-like kinase 1
PRAME preferentially expressed antigen in melanoma
PRC1 protein regulator of cytokinesis 1
PRKCA protein kinase C, alpha
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSRC1 proline/serine-rich coiled-coil 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTTG1 pituitary tumor-transforming 1
RUFY3 RUN and FYVE domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SF1 splicing factor 1
SFPQ splicing factor proline/glutamine-rich
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOX11 SRY (sex determining region Y)-box 11
SRP72 signal recognition particle 72kDa
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2S ubiquitin-conjugating enzyme E2S
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta