BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K59456551_l-glutamic acid, n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- [cas]_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
C6ORF48 chromosome 6 open reading frame 48
CERS6 ceramide synthase 6
COCH cochlin
CST3 cystatin C
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
DSP desmoplakin
ERBB2 erb-b2 receptor tyrosine kinase 2
FCGBP Fc fragment of IgG binding protein
FGB fibrinogen beta chain
GPX2 glutathione peroxidase 2
IGFBP6 insulin-like growth factor binding protein 6
IQGAP2 IQ motif containing GTPase activating protein 2
KAT6B K(lysine) acetyltransferase 6B
KLF9 Kruppel-like factor 9
LGALS4 lectin, galactoside-binding, soluble, 4
LTBP3 latent transforming growth factor beta binding protein 3
MAP1B microtubule-associated protein 1B
PDGFA platelet-derived growth factor alpha polypeptide
PFKL phosphofructokinase, liver
S100A7 S100 calcium binding protein A7
SDC4 syndecan 4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SPEN spen family transcriptional repressor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFF1 trefoil factor 1
TJP2 tight junction protein 2
TKTL1 transketolase-like 1
TM4SF4 transmembrane 4 L six family member 4
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XPO7 exportin 7
ZIC1 Zic family member 1

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AMD1 adenosylmethionine decarboxylase 1
BCL6 B-cell CLL/lymphoma 6
CAMP cathelicidin antimicrobial peptide
CD24 CD24 molecule
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIC4 chloride intracellular channel 4
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPYSL3 dihydropyrimidinase-like 3
EDNRB endothelin receptor type B
EGFL6 EGF-like-domain, multiple 6
EIF5 eukaryotic translation initiation factor 5
EPYC epiphycan
ESRP1 epithelial splicing regulatory protein 1
EVI2A ecotropic viral integration site 2A
GAL galanin/GMAP prepropeptide
HIST1H1C histone cluster 1, H1c
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R1 interleukin 1 receptor, type I
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
KRT23 keratin 23, type I
LMCD1 LIM and cysteine-rich domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR6 lysophosphatidic acid receptor 6
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
NCK1 NCK adaptor protein 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSRC1 proline/serine-rich coiled-coil 1
RGCC regulator of cell cycle
RPIA ribose 5-phosphate isomerase A
RTN2 reticulon 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC38A2 solute carrier family 38, member 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TACSTD2 tumor-associated calcium signal transducer 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)