BRD-K59369769_tozasertib_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K59369769_tozasertib_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ASB13 ankyrin repeat and SOCS box containing 13
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CLU clusterin
COL8A2 collagen, type VIII, alpha 2
CRYAB crystallin, alpha B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO1 forkhead box O1
GAB2 GRB2-associated binding protein 2
GM2A GM2 ganglioside activator
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISYNA1 inositol-3-phosphate synthase 1
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
NELL2 NEL-like 2 (chicken)
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTS neurotensin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLXNC1 plexin C1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
PXDN peroxidasin
PYCARD PYD and CARD domain containing
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERINC5 serine incorporator 5
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
STX3 syntaxin 3
SULF1 sulfatase 1
TBX3 T-box 3
TCEAL2 transcription elongation factor A (SII)-like 2
TOX3 TOX high mobility group box family member 3
TRAPPC6A trafficking protein particle complex 6A
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HJURP Holliday junction recognition protein
IFRD2 interferon-related developmental regulator 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NEIL3 nei endonuclease VIII-like 3 (E. coli)
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PLK4 polo-like kinase 4
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKD3 protein kinase D3
PROM1 prominin 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SMC2 structural maintenance of chromosomes 2
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein