BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
AURKA aurora kinase A
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CAST calpastatin
CCNA2 cyclin A2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP55 centrosomal protein 55kDa
CHN1 chimerin 1
CIT citron rho-interacting serine/threonine kinase
CRELD2 cysteine-rich with EGF-like domains 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
EMP2 epithelial membrane protein 2
EPAS1 endothelial PAS domain protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FN1 fibronectin 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
HMGB3 high mobility group box 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KIAA0355 KIAA0355
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LDLR low density lipoprotein receptor
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MT1F metallothionein 1F
NAV2 neuron navigator 2
NEK2 NIMA-related kinase 2
NKX2-1 NK2 homeobox 1
NPY1R neuropeptide Y receptor Y1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PLK1 polo-like kinase 1
PPL periplakin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SQLE squalene epoxidase
STXBP1 syntaxin binding protein 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TPX2 TPX2, microtubule-associated

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
AKR1C3 aldo-keto reductase family 1, member C3
AOX1 aldehyde oxidase 1
B3GNT1
CA12 carbonic anhydrase XII
CD200 CD200 molecule
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COX11 COX11 cytochrome c oxidase copper chaperone
FAR2 fatty acyl CoA reductase 2
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
HOMER1 homer scaffolding protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IQGAP2 IQ motif containing GTPase activating protein 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
LYZ lysozyme
NME1 NME/NM23 nucleoside diphosphate kinase 1
NRCAM neuronal cell adhesion molecule
PPA2 pyrophosphatase (inorganic) 2
PRKCA protein kinase C, alpha
PRNP prion protein
RFK riboflavin kinase
TARP TCR gamma alternate reading frame protein
TCTA T-cell leukemia translocation altered
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2