BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

29 genes differentially expressed following the BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
CAST calpastatin
CFI complement factor I
COL10A1 collagen, type X, alpha 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HP haptoglobin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IL17RB interleukin 17 receptor B
ITM2C integral membrane protein 2C
LTF lactotransferrin
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
THY1 Thy-1 cell surface antigen
TP53I3 tumor protein p53 inducible protein 3

decreased expression

Symbol Name
HCAR3 hydroxycarboxylic acid receptor 3
HMGA2 high mobility group AT-hook 2
KIAA0125 KIAA0125
LIPA lipase A, lysosomal acid, cholesterol esterase
LUM lumican
PROM1 prominin 1
PTCH1 patched 1