BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

241 genes differentially expressed following the BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANO10 anoctamin 10
APOD apolipoprotein D
AREG amphiregulin
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPA3 carboxypeptidase A3 (mast cell)
CPNE1 copine I
CPT1A carnitine palmitoyltransferase 1A (liver)
CTGF connective tissue growth factor
CUTA cutA divalent cation tolerance homolog (E. coli)
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DSP desmoplakin
EIF3D eukaryotic translation initiation factor 3, subunit D
ELF1 E74-like factor 1 (ets domain transcription factor)
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
HEBP1 heme binding protein 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IP6K2 inositol hexakisphosphate kinase 2
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KIZ kizuna centrosomal protein
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MKRN1 makorin ring finger protein 1
MPO myeloperoxidase
MT1X metallothionein 1X
MVP major vault protein
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSR2 odd-skipped related transciption factor 2
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RAB13 RAB13, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK1 salt-inducible kinase 1
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TNS3 tensin 3
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TSC22D3 TSC22 domain family, member 3
VCAN versican
VGLL4 vestigial-like family member 4
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZMYND8 zinc finger, MYND-type containing 8
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CA9 carbonic anhydrase IX
CACYBP calcyclin binding protein
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNE2 cyclin E2
CD320 CD320 molecule
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKB creatine kinase, brain
CKS1B CDC28 protein kinase regulatory subunit 1B
CMC2 C-x(9)-C motif containing 2
COPS3 COP9 signalosome subunit 3
CPE carboxypeptidase E
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DOK5 docking protein 5
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EED embryonic ectoderm development
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FH fumarate hydratase
FHL1 four and a half LIM domains 1
GALE UDP-galactose-4-epimerase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GLRX2 glutaredoxin 2
GTF2A2 general transcription factor IIA, 2, 12kDa
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
HSPA14 heat shock 70kDa protein 14
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
MEOX2 mesenchyme homeobox 2
MEX3D mex-3 RNA binding family member D
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSAT1 phosphoserine aminotransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A6 S100 calcium binding protein A6
SCG2 secretogranin II
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLBP stem-loop binding protein
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC2 structural maintenance of chromosomes 2
SPC25 SPC25, NDC80 kinetochore complex component
SUB1 SUB1 homolog (S. cerevisiae)
TAGLN2 transgelin 2
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM38B transmembrane protein 38B
TMEM70 transmembrane protein 70
TMPO thymopoietin
TNC tenascin C
TWF1 twinfilin actin binding protein 1
UBE2M ubiquitin-conjugating enzyme E2M
UBE2N ubiquitin-conjugating enzyme E2N
UBE2S ubiquitin-conjugating enzyme E2S
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UNG uracil-DNA glycosylase
ZWINT ZW10 interacting kinetochore protein