BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ARG2 arginase 2
AURKA aurora kinase A
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CRABP1 cellular retinoic acid binding protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
FABP4 fatty acid binding protein 4, adipocyte
GPM6B glycoprotein M6B
INSIG1 insulin induced gene 1
MAN1A1 mannosidase, alpha, class 1A, member 1
NDC80 NDC80 kinetochore complex component
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PPP1R16B protein phosphatase 1, regulatory subunit 16B
SC5D sterol-C5-desaturase
SKAP2 src kinase associated phosphoprotein 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STS steroid sulfatase (microsomal), isozyme S
STXBP2 syntaxin binding protein 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AMPD3 adenosine monophosphate deaminase 3
C8ORF4 chromosome 8 open reading frame 4
CAPG capping protein (actin filament), gelsolin-like
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CP ceruloplasmin (ferroxidase)
DCBLD2 discoidin, CUB and LCCL domain containing 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPCAM epithelial cell adhesion molecule
EPHA2 EPH receptor A2
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLA-DMB major histocompatibility complex, class II, DM beta
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLF10 Kruppel-like factor 10
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
LOC100505650 uncharacterized LOC100505650
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MET MET proto-oncogene, receptor tyrosine kinase
MUC16 mucin 16, cell surface associated
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NPY neuropeptide Y
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PRKCD protein kinase C, delta
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
S100A2 S100 calcium binding protein A2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TSC22D1 TSC22 domain family, member 1
WFDC2 WAP four-disulfide core domain 2
ZNF365 zinc finger protein 365