BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K59369769_N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide VX-680_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CBS cystathionine-beta-synthase
CFD complement factor D (adipsin)
CLU clusterin
COMP cartilage oligomeric matrix protein
CPD carboxypeptidase D
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL1R1 interleukin 1 receptor, type I
KDM5D lysine (K)-specific demethylase 5D
METTL7A methyltransferase like 7A
NQO1 NAD(P)H dehydrogenase, quinone 1
PHYH phytanoyl-CoA 2-hydroxylase
PIR pirin (iron-binding nuclear protein)
PRSS21 protease, serine, 21 (testisin)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP4 retinol binding protein 4, plasma
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ADM adrenomedullin
AIM2 absent in melanoma 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCDC47 coiled-coil domain containing 47
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
DUSP6 dual specificity phosphatase 6
EAF2 ELL associated factor 2
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXT1 exostosin glycosyltransferase 1
FAM57A family with sequence similarity 57, member A
FN1 fibronectin 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GRWD1 glutamate-rich WD repeat containing 1
HSPA8 heat shock 70kDa protein 8
IDS iduronate 2-sulfatase
IER2 immediate early response 2
KRT6B keratin 6B, type II
LOC100505650 uncharacterized LOC100505650
MACF1 microtubule-actin crosslinking factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PON3 paraoxonase 3
PRKCA protein kinase C, alpha
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SDC1 syndecan 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
TLK2 tousled-like kinase 2
TMEM45A transmembrane protein 45A
TRAPPC3 trafficking protein particle complex 3
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
UBE2J1 ubiquitin-conjugating enzyme E2, J1
XIST X inactive specific transcript (non-protein coding)
XPO7 exportin 7