BRD-K59332007_2h-indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)- [cas]_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K59332007_2h-indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)- [cas]_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
ASS1 argininosuccinate synthase 1
BCL6 B-cell CLL/lymphoma 6
C10ORF10 chromosome 10 open reading frame 10
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD302 CD302 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP1 dual specificity phosphatase 1
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EMP2 epithelial membrane protein 2
FKBP5 FK506 binding protein 5
FOS FBJ murine osteosarcoma viral oncogene homolog
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
IFI16 interferon, gamma-inducible protein 16
IFITM3 interferon induced transmembrane protein 3
KCTD12 potassium channel tetramerization domain containing 12
KLF2 Kruppel-like factor 2
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LTF lactotransferrin
MAOA monoamine oxidase A
MAP3K7CL MAP3K7 C-terminal like
MEIS1 Meis homeobox 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSLN mesothelin
MSMB microseminoprotein, beta-
MYH11 myosin, heavy chain 11, smooth muscle
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NOX4 NADPH oxidase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSBPL8 oxysterol binding protein-like 8
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRL platelet-derived growth factor receptor-like
PDLIM3 PDZ and LIM domain 3
PER1 period circadian clock 1
PIP prolactin-induced protein
PKP2 plakophilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPL periplakin
PTPRC protein tyrosine phosphatase, receptor type, C
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SPEN spen family transcriptional repressor
SRRM2 serine/arginine repetitive matrix 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYBU syntabulin (syntaxin-interacting)
TAGLN transgelin
TLR4 toll-like receptor 4
TMEM45A transmembrane protein 45A
TSC22D3 TSC22 domain family, member 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VNN1 vanin 1
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD200 CD200 molecule
CD24 CD24 molecule
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COG4 component of oligomeric golgi complex 4
CRABP2 cellular retinoic acid binding protein 2
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTSZ cathepsin Z
CXCL12 chemokine (C-X-C motif) ligand 12
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
FBN2 fibrillin 2
FBXO11 F-box protein 11
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA2 GATA binding protein 2
GSTM3 glutathione S-transferase mu 3 (brain)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HOXB7 homeobox B7
IER3 immediate early response 3
IRF1 interferon regulatory factor 1
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
NLRP2 NLR family, pyrin domain containing 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PTN pleiotrophin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL37A ribosomal protein L37a
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
TFF3 trefoil factor 3 (intestinal)
TMEM106B transmembrane protein 106B
TPBG trophoblast glycoprotein
TRIB2 tribbles pseudokinase 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WARS tryptophanyl-tRNA synthetase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18
ZNF586 zinc finger protein 586