BRD-K59317601_INK-128_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

281 genes differentially expressed following the BRD-K59317601_INK-128_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPN asporin
BIK BCL2-interacting killer (apoptosis-inducing)
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCDC92 coiled-coil domain containing 92
CCNG1 cyclin G1
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CRISP3 cysteine-rich secretory protein 3
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSK cathepsin K
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DARS aspartyl-tRNA synthetase
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRN granulin
GSN gelsolin
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL1R1 interleukin 1 receptor, type I
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MEIS1 Meis homeobox 1
MFAP5 microfibrillar associated protein 5
MKRN1 makorin ring finger protein 1
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MT1G metallothionein 1G
MT1X metallothionein 1X
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
ORAI3 ORAI calcium release-activated calcium modulator 3
PALLD palladin, cytoskeletal associated protein
PAWR PRKC, apoptosis, WT1, regulator
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLA2G16 phospholipase A2, group XVI
PLAU plasminogen activator, urokinase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPL periplakin
PTEN phosphatase and tensin homolog
QPCT glutaminyl-peptide cyclotransferase
RAI2 retinoic acid induced 2
RAP1GAP RAP1 GTPase activating protein
RBPMS RNA binding protein with multiple splicing
RHOQ ras homolog family member Q
RND3 Rho family GTPase 3
RPL22 ribosomal protein L22
RRAGD Ras-related GTP binding D
S100A14 S100 calcium binding protein A14
SAMD4A sterile alpha motif domain containing 4A
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SH3YL1 SH3 and SYLF domain containing 1
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD3 SMAD family member 3
SORBS3 sorbin and SH3 domain containing 3
SPATA20 spermatogenesis associated 20
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SVIL supervillin
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGM2 transglutaminase 2
TM7SF2 transmembrane 7 superfamily member 2
TMC5 transmembrane channel-like 5
TMEM30B transmembrane protein 30B
TMPRSS2 transmembrane protease, serine 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TRIM29 tripartite motif containing 29
TRIM33 tripartite motif containing 33
TRIM8 tripartite motif containing 8
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
VCL vinculin
WASL Wiskott-Aldrich syndrome-like
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOB apolipoprotein B
ASCL1 achaete-scute family bHLH transcription factor 1
ASF1A anti-silencing function 1A histone chaperone
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
C20ORF27 chromosome 20 open reading frame 27
CA2 carbonic anhydrase II
CALR calreticulin
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPN centromere protein N
CHI3L2 chitinase 3-like 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CIT citron rho-interacting serine/threonine kinase
COL9A3 collagen, type IX, alpha 3
COPS7A COP9 signalosome subunit 7A
CRLF1 cytokine receptor-like factor 1
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCK deoxycytidine kinase
DDA1 DET1 and DDB1 associated 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPC3 glypican 3
GRWD1 glutamate-rich WD repeat containing 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HN1 hematological and neurological expressed 1
HP haptoglobin
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISOC1 isochorismatase domain containing 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRAS Kirsten rat sarcoma viral oncogene homolog
LMNB1 lamin B1
LMO4 LIM domain only 4
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NES nestin
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POU4F1 POU class 4 homeobox 1
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB5C RAB5C, member RAS oncogene family
RAD51C RAD51 paralog C
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCRG1 stimulator of chondrogenesis 1
SDC2 syndecan 2
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SRSF2 serine/arginine-rich splicing factor 2
STK17A serine/threonine kinase 17a
TAGLN2 transgelin 2
TCTN1 tectonic family member 1
TMSB15A thymosin beta 15a
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein