BRD-K59273480_3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6(3H,7H)-dione HOC-1_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K59273480_3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6(3H,7H)-dione HOC-1_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AREG amphiregulin
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CCL20 chemokine (C-C motif) ligand 20
CCNA1 cyclin A1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CLDN10 claudin 10
ECHDC3 enoyl CoA hydratase domain containing 3
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KLK8 kallikrein-related peptidase 8
MAPK13 mitogen-activated protein kinase 13
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1 metastasis suppressor 1
NPTX2 neuronal pentraxin II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLBD1 phospholipase B domain containing 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSD3 pleckstrin and Sec7 domain containing 3
PVALB parvalbumin
RAB21 RAB21, member RAS oncogene family
SRRM2 serine/arginine repetitive matrix 2
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
WT1 Wilms tumor 1

decreased expression

Symbol Name
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CFD complement factor D (adipsin)
ENO2 enolase 2 (gamma, neuronal)
FABP4 fatty acid binding protein 4, adipocyte
FKBP11 FK506 binding protein 11, 19 kDa
GPM6B glycoprotein M6B
HOXC6 homeobox C6
IGKC immunoglobulin kappa constant
INSIG1 insulin induced gene 1
LCN2 lipocalin 2
LIPG lipase, endothelial
MBNL1 muscleblind-like splicing regulator 1
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MSX1 msh homeobox 1
PCP4 Purkinje cell protein 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRR7 proline rich 7 (synaptic)
RAD23B RAD23 homolog B (S. cerevisiae)
RFC5 replication factor C (activator 1) 5, 36.5kDa
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPTSSA serine palmitoyltransferase, small subunit A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
WIF1 WNT inhibitory factor 1