BRD-K58772419_AZD-6482_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K58772419_AZD-6482_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C14ORF132 chromosome 14 open reading frame 132
CCND1 cyclin D1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CSRP1 cysteine and glycine-rich protein 1
DAAM2 dishevelled associated activator of morphogenesis 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
FZD10 frizzled class receptor 10
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGL immunoglobulin lambda locus
INTS3 integrator complex subunit 3
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
LIMCH1 LIM and calponin homology domains 1
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
SEPT10 septin 10
SGCE sarcoglycan, epsilon
SPRY2 sprouty homolog 2 (Drosophila)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
BAALC brain and acute leukemia, cytoplasmic
CA2 carbonic anhydrase II
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNTT DNA nucleotidylexotransferase
ECI2 enoyl-CoA delta isomerase 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP7 fatty acid binding protein 7, brain
FAS Fas cell surface death receptor
FKBP14 FK506 binding protein 14, 22 kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER2 homer scaffolding protein 2
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
LAMP5 lysosomal-associated membrane protein family, member 5
MTERF3 mitochondrial transcription termination factor 3
PGM1 phosphoglucomutase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PSPH phosphoserine phosphatase
SMYD3 SET and MYND domain containing 3
SUB1 SUB1 homolog (S. cerevisiae)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)