BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C2 aldo-keto reductase family 1, member C2
ALDOA aldolase A, fructose-bisphosphate
ANKRD12 ankyrin repeat domain 12
ARC activity-regulated cytoskeleton-associated protein
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CALCA calcitonin-related polypeptide alpha
CCND2 cyclin D2
CCNL1 cyclin L1
COL10A1 collagen, type X, alpha 1
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GLA galactosidase, alpha
GLS glutaminase
GOLGA8A golgin A8 family, member A
GUSBP3 glucuronidase, beta pseudogene 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRF4 interferon regulatory factor 4
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIF14 kinesin family member 14
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LOC100272216 uncharacterized LOC100272216
LRRC15 leucine rich repeat containing 15
LTBP2 latent transforming growth factor beta binding protein 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEG3 maternally expressed 3 (non-protein coding)
MFAP5 microfibrillar associated protein 5
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NRCAM neuronal cell adhesion molecule
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
RBP4 retinol binding protein 4, plasma
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
TRA2A transformer 2 alpha homolog (Drosophila)
TSPYL2 TSPY-like 2
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
AGTR1 angiotensin II receptor, type 1
AKAP7 A kinase (PRKA) anchor protein 7
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGAP6 Rho GTPase activating protein 6
ATMIN ATM interactor
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
C1ORF116 chromosome 1 open reading frame 116
C4ORF27 chromosome 4 open reading frame 27
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CANT1 calcium activated nucleotidase 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCXR dicarbonyl/L-xylulose reductase
DEGS1 delta(4)-desaturase, sphingolipid 1
ECI2 enoyl-CoA delta isomerase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN1 ER lipid raft associated 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA2 GATA binding protein 2
GBAS glioblastoma amplified sequence
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX1 glutathione peroxidase 1
HES1 hes family bHLH transcription factor 1
HMBS hydroxymethylbilane synthase
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JAG1 jagged 1
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KRT7 keratin 7, type II
LRRN3 leucine rich repeat neuronal 3
LTF lactotransferrin
MARCKSL1 MARCKS-like 1
MLPH melanophilin
MME membrane metallo-endopeptidase
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
OXTR oxytocin receptor
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSPH phosphoserine phosphatase
PTGES prostaglandin E synthase
PTN pleiotrophin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM47 RNA binding motif protein 47
S100A12 S100 calcium binding protein A12
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TARP TCR gamma alternate reading frame protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMPRSS2 transmembrane protease, serine 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
UROD uroporphyrinogen decarboxylase