BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSK cathepsin K
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGL2 fibrinogen-like 2
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IL6 interleukin 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLF5 Kruppel-like factor 5 (intestinal)
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PALLD palladin, cytoskeletal associated protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD21 RAD21 homolog (S. pombe)
RANBP2 RAN binding protein 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SELENBP1 selenium binding protein 1
SIK1 salt-inducible kinase 1
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TMEM176B transmembrane protein 176B
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
WASL Wiskott-Aldrich syndrome-like
WT1 Wilms tumor 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
CIAPIN1 cytokine induced apoptosis inhibitor 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSH cathepsin H
FSTL1 follistatin-like 1
GPC3 glypican 3
KIF20A kinesin family member 20A
LMO2 LIM domain only 2 (rhombotin-like 1)
NREP neuronal regeneration related protein
NTS neurotensin
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PSPH phosphoserine phosphatase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TYRP1 tyrosinase-related protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)