BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BMP7 bone morphogenetic protein 7
CA4 carbonic anhydrase IV
CD9 CD9 molecule
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT20 keratin 20, type I
LCN2 lipocalin 2
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MPO myeloperoxidase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
OLFM4 olfactomedin 4
PRTN3 proteinase 3
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
STC1 stanniocalcin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPSB2 tryptase beta 2 (gene/pseudogene)
VEGFA vascular endothelial growth factor A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ARMCX6 armadillo repeat containing, X-linked 6
ATG3 autophagy related 3
BAD BCL2-associated agonist of cell death
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
DLD dihydrolipoamide dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
G0S2 G0/G1 switch 2
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LPAR1 lysophosphatidic acid receptor 1
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MDFIC MyoD family inhibitor domain containing
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NXT2 nuclear transport factor 2-like export factor 2
OAT ornithine aminotransferase
OXTR oxytocin receptor
PBK PDZ binding kinase
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PTDSS1 phosphatidylserine synthase 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
TGM2 transglutaminase 2
TMEM14A transmembrane protein 14A
TRIP6 thyroid hormone receptor interactor 6
TSPAN13 tetraspanin 13
TYMS thymidylate synthetase
WFDC2 WAP four-disulfide core domain 2
ZNF217 zinc finger protein 217