BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K58214070_N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AGR2 anterior gradient 2
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CLEC11A C-type lectin domain family 11, member A
CPB1 carboxypeptidase B1 (tissue)
CPVL carboxypeptidase, vitellogenic-like
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EYA1 EYA transcriptional coactivator and phosphatase 1
F13A1 coagulation factor XIII, A1 polypeptide
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GPATCH8 G patch domain containing 8
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
IL1R2 interleukin 1 receptor, type II
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTF2 metal response element binding transcription factor 2
NQO1 NAD(P)H dehydrogenase, quinone 1
ODC1 ornithine decarboxylase 1
PENK proenkephalin
PIR pirin (iron-binding nuclear protein)
PODXL podocalyxin-like
PPAP2B phosphatidic acid phosphatase type 2B
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYBU syntabulin (syntaxin-interacting)
TAC1 tachykinin, precursor 1
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BCHE butyrylcholinesterase
BCL2L1 BCL2-like 1
CHIT1 chitinase 1 (chitotriosidase)
COL5A2 collagen, type V, alpha 2
CTSH cathepsin H
DCN decorin
EGFL6 EGF-like-domain, multiple 6
FILIP1L filamin A interacting protein 1-like
GUSB glucuronidase, beta
IGHM immunoglobulin heavy constant mu
ITGB4 integrin, beta 4
MMP9 matrix metallopeptidase 9
NUP85 nucleoporin 85kDa
PEG10 paternally expressed 10
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC38A2 solute carrier family 38, member 2
STAP1 signal transducing adaptor family member 1
SUMO2 small ubiquitin-like modifier 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VNN1 vanin 1